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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC2
All Species:
22.73
Human Site:
Y1186
Identified Species:
50
UniProt:
P49815
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49815
NP_000539.2
1807
200608
Y1186
E
K
T
N
L
A
A
Y
V
P
L
L
T
Q
G
Chimpanzee
Pan troglodytes
XP_523477
1803
200189
Y1186
E
K
T
N
L
A
A
Y
V
P
L
L
T
Q
G
Rhesus Macaque
Macaca mulatta
XP_001083256
1807
200600
Y1186
E
K
T
N
L
A
A
Y
V
P
L
L
T
Q
G
Dog
Lupus familis
XP_852047
1813
201226
Y1186
E
K
T
S
L
A
A
Y
V
P
L
L
T
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61037
1814
202053
Y1186
E
K
T
N
L
A
A
Y
V
P
L
L
T
Q
G
Rat
Rattus norvegicus
P49816
1809
201259
Y1186
E
K
A
N
L
A
A
Y
V
P
L
L
T
Q
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516748
947
107028
L362
A
V
S
W
D
V
L
L
D
I
L
E
R
L
L
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695912
1128
123244
T543
A
E
F
V
P
M
L
T
Q
G
W
A
E
I
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524177
1847
204101
R1257
A
K
A
R
A
L
Q
R
Q
E
E
I
H
S
V
Honey Bee
Apis mellifera
XP_395739
1813
206229
D1189
M
Q
F
E
T
N
I
D
F
P
V
Y
D
I
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786931
1947
217345
I1286
N
T
S
W
I
M
R
I
Q
N
G
G
A
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.9
91.2
N.A.
88.9
91
N.A.
44.1
N.A.
N.A.
35.8
N.A.
29.8
38.2
N.A.
31.1
Protein Similarity:
100
99
99
94.6
N.A.
92.2
93.9
N.A.
48.3
N.A.
N.A.
44.3
N.A.
49.7
58.6
N.A.
48.9
P-Site Identity:
100
100
100
93.3
N.A.
100
93.3
N.A.
6.6
N.A.
N.A.
0
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
13.3
N.A.
N.A.
6.6
N.A.
13.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
0
19
0
10
55
55
0
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
10
10
0
0
0
10
0
0
% D
% Glu:
55
10
0
10
0
0
0
0
0
10
10
10
10
0
0
% E
% Phe:
0
0
19
0
0
0
0
0
10
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
10
10
0
0
55
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
10
0
10
10
0
10
0
10
0
19
0
% I
% Lys:
0
64
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
55
10
19
10
0
0
64
55
0
19
19
% L
% Met:
10
0
0
0
0
19
0
0
0
0
0
0
0
0
10
% M
% Asn:
10
0
0
46
0
10
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
64
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
10
0
28
0
0
0
0
55
0
% Q
% Arg:
0
0
0
10
0
0
10
10
0
0
0
0
10
0
0
% R
% Ser:
0
0
19
10
0
0
0
0
0
0
0
0
0
10
0
% S
% Thr:
0
10
46
0
10
0
0
10
0
0
0
0
55
0
0
% T
% Val:
0
10
0
10
0
10
0
0
55
0
10
0
0
0
10
% V
% Trp:
0
0
0
19
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
55
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _